Author

Jie Li

The University of Texas Southwestern Medical CenterORCID 0000-0002-1059-280XUnclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jie Li17 papers · Cancer Hospital of Shantou University Medical College

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Xiao-Chen BaiiD· 3 shared Jay Xiaojun TaniD· 2 shared Xuewu ZhangiD· 2 shared Zhijian J. CheniD· 2 shared Albert HungiD· 1 shared Bo LviD· 1 shared Brian CoventryiD· 1 shared Catherine HalliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

Xiao-Chen BaiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Regulation of STING activation by phosphoinositide and cholesterol

Jie Li, Jay Xiaojun Tan, Zhijian J. Chen, Xuewu Zhang, Xiao-Chen Bai

This study identifies phosphoinositides and cholesterol as regulators of STING activation by promoting its oligomerization and translocation.

Nature · Feb 4, 2026Peer-reviewedImmunology

PtdIns(3,5)P2 Is an Endogenous Ligand of STING in Innate Immune Signaling

Jay Xiaojun Tan, Bo Lv, Jie Li, Tuo Li, Fenghe Du, Xiang Chen, Xuewu Zhang, Xiao-Chen Bai, Zhijian J. Chen

This study identifies PtdIns(3,5)P2 as an endogenous ligand of STING that cooperates with cGAMP to activate innate immune signaling.

bioRxiv · Dec 29, 2025 · PreprintBiochemistry

Tuning Insulin Receptor Signaling Using De Novo Designed Agonists

Xinru Wang, Sarah Caixeta Cardoso, Kai Cai, Preetham Venkatesh, Albert Hung, Michelle Ng, Catherine Hall, Brian Coventry, David S. Lee, Rishabh Chowhan, Stacey Gerben, Jie Li, Weidong An, Mara Hon, Michael C. Gao, , David A. Baker

This paper designs synthetic insulin receptor agonists that modulate receptor conformation and signaling, showing improved potency and activity in disease mutants.

Molecular Cell · Oct 15, 2025Peer-reviewedBioengineering