Author

Michelle Ng

Columbia University Irving Medical CenterPrimary ORCID profile (0000-0001-5113-3733 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Michelle NgiD2 papers · University of British Columbia

Biology Disciplines

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Bioengineering· 1 Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Albert HungiD· 2 shared David A. BakeriD· 2 shared Domenico AcciliiD· 2 shared Eunhee ChoiiD· 2 shared Sarah Caixeta Cardoso· 2 shared Xinru WangiD· 2 shared Ava V. Papetti· 1 shared Brian CoventryiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersPharmacology & Toxicology

Albert HungORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6-Dependent Interneuron Dysmaturation

Ava V. Papetti, Ziyuan Ma, Michelle Ng, Mengmeng Jin, Steven W. Levison, Peng Jiang

This study uses human brain organoids to show that transient IL-6 exposure during prenatal development disrupts interneuron maturation and subtype specification, linking it to neurodevelopmental disorders.

bioRxiv · May 28, 2026 · PreprintNeuroscience

Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistance

Albert Hung, Xinru Wang, Michael Gao, Michelle Ng, Denys Oliinyk, Riley R. Weaver, Elisabeth Zollbrecht, Sarah Caixeta Cardoso, Gregory Sebastien Ronel, Chloe A Paolucci, Jianxiang Ye, Qing Fan, Elizabeth M. Rhea, Matthias Mann, David A. Baker, , Eunhee Choi

This study develops a de novo insulin receptor agonist, RF-409, which effectively treats severe insulin resistance in a mouse model by activating a mutant receptor and improving glucose homeostasis.

bioRxiv · May 7, 2026 · PreprintPharmacology & Toxicology

Tuning Insulin Receptor Signaling Using De Novo Designed Agonists

Xinru Wang, Sarah Caixeta Cardoso, Kai Cai, Preetham Venkatesh, Albert Hung, Michelle Ng, Catherine Hall, Brian Coventry, David S. Lee, Rishabh Chowhan, Stacey Gerben, Jie Li, Weidong An, Mara Hon, Michael C. Gao, , David A. Baker

This paper designs synthetic insulin receptor agonists that modulate receptor conformation and signaling, showing improved potency and activity in disease mutants.

Molecular Cell · Oct 15, 2025Peer-reviewedBioengineering