Author

Kaipeng Hou

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexander N. VolkoviD· 1 shared G.J. CorreyiD· 1 shared Ian J. BakanasiD· 1 shared Ivan V. KorendovychiD· 1 shared J.T. BieliD· 1 shared James S. FraseriD· 1 shared Jason E. GestwickiiD· 1 shared Lei LuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Alexander N. VolkovORCID

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1 paper

Recent·Most cited

Emergence of specific binding and catalysis from a designed generalist binding protein

Yuda Chen, Sagar Bhattacharya, Lena Bergmann, G.J. Correy, Sophia K. Tan, Kaipeng Hou, J.T. Biel, Lei Lu, Ian J. Bakanas, Jason E. Gestwicki, Alexander N. Volkov, Ivan V. Korendovych, Nicholas F. Polizzi, James S. Fraser, William F. DeGrado

This study shows how a designed generalist binding protein can evolve into specific functions like a fluorophore binder and an efficient enzyme through weak, promiscuous interactions.

Nature Chemistry · May 4, 2026Peer-reviewedBiophysics