Author

Yuda Chen

University of California, San FranciscoPrimary ORCID profile (0000-0002-5399-1720 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Yuda CheniD4 papers · Rice University

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexander N. VolkoviD· 1 shared G.J. CorreyiD· 1 shared Ian J. BakanasiD· 1 shared Ivan V. KorendovychiD· 1 shared J.T. BieliD· 1 shared James S. FraseriD· 1 shared Jason E. GestwickiiD· 1 shared Kaipeng Hou· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Alexander N. VolkovORCID

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1 paper

Recent·Most cited

Emergence of specific binding and catalysis from a designed generalist binding protein

Yuda Chen, Sagar Bhattacharya, Lena Bergmann, G.J. Correy, Sophia K. Tan, Kaipeng Hou, J.T. Biel, Lei Lu, Ian J. Bakanas, Jason E. Gestwicki, Alexander N. Volkov, Ivan V. Korendovych, Nicholas F. Polizzi, James S. Fraser, William F. DeGrado

This study shows how a designed generalist binding protein can evolve into specific functions like a fluorophore binder and an efficient enzyme through weak, promiscuous interactions.

Nature Chemistry · May 4, 2026Peer-reviewedBiophysics