Author

Sagar Bhattacharya

University of California, San FranciscoORCID 0000-0002-8020-9255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander N. VolkoviD· 2 shared Ivan V. KorendovychiD· 2 shared William F. DeGradoiD· 2 shared David N. BerataniD· 1 shared G.J. CorreyiD· 1 shared Gessica M. Adornato· 1 shared Hyunil JoiD· 1 shared Ian J. BakanasiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Alexander N. VolkovORCID

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2 papers

Recent·Most cited

Interplay of stability and dynamics in the optimization of a highly proficient de novo enzyme

Sagar Bhattacharya, Gessica M. Adornato, Yuda Chen, Xiao Huang, Wael El Yazidi Mouloud, Hyunil Jo, Alexander N. Volkov, Ivan V. Korendovych, Yang Yang, David N. Beratan, Peng Liu, William F. DeGrado

This study identifies features contributing to catalytic efficiency in a de novo enzyme through computational design and directed evolution, showing how stability and dynamics interplay in enzyme optimization.

bioRxiv · Sep 10, 2026 · PreprintBiochemistry

Emergence of specific binding and catalysis from a designed generalist binding protein

Yuda Chen, Sagar Bhattacharya, Lena Bergmann, G.J. Correy, Sophia K. Tan, Kaipeng Hou, J.T. Biel, Lei Lu, Ian J. Bakanas, Jason E. Gestwicki, Alexander N. Volkov, Ivan V. Korendovych, Nicholas F. Polizzi, James S. Fraser, William F. DeGrado

This study shows how a designed generalist binding protein can evolve into specific functions like a fluorophore binder and an efficient enzyme through weak, promiscuous interactions.

Nature Chemistry · May 4, 2026Peer-reviewedBiophysics