Author

J.T. Biel

University of California, San FranciscoORCID 0000-0002-0935-8362Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Alexander N. VolkoviD· 1 shared G.J. CorreyiD· 1 shared Ian J. BakanasiD· 1 shared Ivan V. KorendovychiD· 1 shared James S. FraseriD· 1 shared Jason E. GestwickiiD· 1 shared Kaipeng Hou· 1 shared Lei LuiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Alexander N. VolkovORCID

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1 paper

Recent·Most cited

BiophysicsNature ChemistryPeer-reviewedMay 4, 2026

Emergence of specific binding and catalysis from a designed generalist binding protein

Yuda Chen, Sagar Bhattacharya, Lena Bergmann…·William F. DeGrado

This study shows how a designed generalist binding protein can evolve into specific functions like a fluorophore binder and an efficient enzyme through weak, promiscuous interactions.

14 citationstop 1%

protein structureexperimental assay

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