Author

Ivan V. Korendovych

Baylor UniversityORCID 0000-0001-8144-783XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander N. VolkoviD· 2 shared Sagar BhattacharyaiD· 2 shared William F. DeGradoiD· 2 shared David N. BerataniD· 1 shared G.J. CorreyiD· 1 shared Gessica M. Adornato· 1 shared Hyunil JoiD· 1 shared Ian J. BakanasiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Alexander N. VolkovORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 10, 2026

Interplay of stability and dynamics in the optimization of a highly proficient de novo enzyme

Sagar Bhattacharya, Gessica M. Adornato, Yuda Chen…·William F. DeGrado

This study identifies features contributing to catalytic efficiency in a de novo enzyme through computational design and directed evolution, showing how stability and dynamics interplay in enzyme optimization.

DOI 10.64898/2026.05.29.728685

proteomicsexperimental assay

𝕏 PostBluesky

BiophysicsNature ChemistryPeer-reviewedMay 4, 2026

Emergence of specific binding and catalysis from a designed generalist binding protein

Yuda Chen, Sagar Bhattacharya, Lena Bergmann…·William F. DeGrado

This study shows how a designed generalist binding protein can evolve into specific functions like a fluorophore binder and an efficient enzyme through weak, promiscuous interactions.

14 citationstop 1%

protein structureexperimental assay

𝕏 PostBluesky