Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence
Marko Rubinić, Yi Yu, Aranzazu Arias-Rojas, Kaisy A Martinez, Wioletta Klimek, Dagmar Frahm, Volker Brinkmann, Nicole Paczia, Kathirvel Alagesan, David Duneau, Igor Iatsenko
This study shows sex differences in Drosophila intestinal metabolism affect infection outcomes, with males clearing pathogens via antioxidant pathways while females experience higher pathogen virulence.
Proceedings of the National Academy of Sciences · Jun 24, 2026Peer-reviewedImmunology