DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease
Kylene P. Daily, Asmaa Badr, Mostafa M. Eltobgy, Shady Z. K. Estfanous, Owen D. Whitham, Michelle H. Tan, Cierra Carafice, Kathrin Krause, Andrew J. McNamara, Kaitlin Hamilton, Samuel Houle, Spandan Gupta, Gauruv A. Gupta, Shruthi Madhu, Julie Fitzgerald, , Amal O. Amer
This study identifies DNA hypomethylation of CASP4 in AD microglia leading to increased CASP4 expression, which promotes neuroinflammation and amyloid-β deposition in Alzheimer's disease.
bioRxiv · Aug 30, 2023 · PreprintNeuroscience