Author

Owen D. Whitham

The Ohio State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

Amal O. AmeriD· 4 shared Asmaa BadriD· 4 shared Gauruv A. Gupta· 4 shared Mostafa M. EltobgyiD· 4 shared Xiaoli ZhangiD· 4 shared Amy WebbiD· 3 shared Heba M. AmeriD· 3 shared Maciej PietrzakiD· 3 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersNeuroscience

Amal O. AmerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection

Mostafa M. Eltobgy, Mohamed M. Shamseldin, Owen D. Whitham, Heba M. Amer, Jeffrey Atkinson, Asmaa Badr, Jesse M. Hall, Gauruv A. Gupta, Yara Y. Hassan, Rabab ElMergawy, Richard Perez, Sarah E. Faber, Maciej Pietrzak, Amy Webb, Xiaoli Zhang, , Amal O. Amer

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

JCI Insight · Sep 21, 2026Peer-reviewedMicrobiology

Gelsolin protects mitochondria and regulates inflammation during Legionella pneumophila infection

Owen D. Whitham, Mostafa M. Eltobgy, Mohamed M. Shamseldin, Asmaa Badr, Richard A Perez, Yara Y. Hassan, Heba M. Amer, Gauruv A. Gupta, Sarah E. Faber, Frank H. Robledo-Avila, Xiaoli Zhang, Maya Mikami, Santiago Partida‐Sánchez, Stephanie M. Seveau, Amal O. Amer

This study shows that gelsolin protects against Legionella pneumophila infection by maintaining mitochondrial health, reducing inflammation, and supporting neutrophil function.

bioRxiv · Aug 20, 2026 · PreprintImmunology

AI-based decoding of long covid cognitive impairments in mice using automated behavioral system and comparative transcriptomic analysis

Heba M. Amer, Mohamed M. Shamseldin, Sarah Faber, Mostafa M. Eltobgy, Amy Webb, Rabab ElMergawy, Michelle Chamblee, Richard Perez, Owen D. Whitham, Asmaa Badr, Gauruv A. Gupta, Jihad I. Omran, Destiny Bissel, Jacob S. Yount, Estelle Cormet‐Boyaka, , Amal O. Amer

This study uses an automated behavioral system and transcriptomic analysis to identify cognitive impairments in mice with long COVID, finding similar transcriptomic changes to humans.

bioRxiv · May 14, 2025 · PreprintNeuroscience

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease

Kylene P. Daily, Asmaa Badr, Mostafa M. Eltobgy, Shady Z. K. Estfanous, Owen D. Whitham, Michelle H. Tan, Cierra Carafice, Kathrin Krause, Andrew J. McNamara, Kaitlin Hamilton, Samuel Houle, Spandan Gupta, Gauruv A. Gupta, Shruthi Madhu, Julie Fitzgerald, , Amal O. Amer

This study identifies DNA hypomethylation of CASP4 in AD microglia leading to increased CASP4 expression, which promotes neuroinflammation and amyloid-β deposition in Alzheimer's disease.

bioRxiv · Aug 30, 2023 · PreprintNeuroscience