Author

Kaitlyn A. Sabo

San Diego State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biochemistry· 1

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Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew L. CooksyiD· 1 shared Andrey A. BobkoviD· 1 shared Brittany M. ConleyiD· 1 shared Christal Dyane SohliD· 1 shared Diego Avellaneda Matteo· 1 shared Elene Albekioni· 1 shared Elizabeth A. KomivesiD· 1 shared Jamie M. SchifferiD· 1 shared

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2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrew L. CooksyORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMay 6, 2024

Active site remodeling in IDH1 mutants drives distinct kinetic and potential resistance mechanisms

Matthew Mealka, Nicole A. Sierra, Diego Avellaneda Matteo…·Christal Dyane Sohl

This study compares the reaction mechanisms of two IDH1 mutants, finding that R132Q has optimized active site conformation for both conventional and neomorphic activity, potentially explaining resistance to inhibitors.

4 citations

humanprotein structure

𝕏 PostBluesky