Author

Jamie M. Schiffer

Vividion Therapeutics (United States)ORCID 0000-0002-0208-6958Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew L. CooksyiD· 1 shared Andrey A. BobkoviD· 1 shared Brittany M. ConleyiD· 1 shared Christal Dyane SohliD· 1 shared Diego Avellaneda Matteo· 1 shared Elene Albekioni· 1 shared Elizabeth A. KomivesiD· 1 shared Kaitlyn A. Sabo· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Andrew L. CooksyORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedMay 6, 2024

Active site remodeling in IDH1 mutants drives distinct kinetic and potential resistance mechanisms

Matthew Mealka, Nicole A. Sierra, Diego Avellaneda Matteo…·Christal Dyane Sohl

This study compares the reaction mechanisms of two IDH1 mutants, finding that R132Q has optimized active site conformation for both conventional and neomorphic activity, potentially explaining resistance to inhibitors.

4 citations

humanprotein structure

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