The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits
Nancy Morones, Predrag Jovanović, Anna Magdalena Sanetra, Kaitlyn Jang, Nareg Keshishian, Zhihan Cui, Edward Novinbakht, Joshua J. Breunig, Anders Hayden Berg, Tamar Pirtskhalava, Selim Chaib, S. Ananth Karumanchi, Tamar Tchkonia, Kätlin Silm, James L. Kirkland, Celine Emmanuelle Riera
This study identifies SONAVP neuron hyperactivity as a driver of aging-related homeostatic deficits and suggests AVP signaling modulation as a therapeutic strategy.
bioRxiv · Nov 3, 2025 · PreprintPhysiology