James L. Kirkland

This study identifies salvianolic acids as natural senolytics that enhance lifespan and healthspan in aged mice by targeting senescent cells through redox modulation and inducing apoptosis and ferroptosis.

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

This study identifies dihydromyricetin as a natural senotherapeutic agent that targets senescent cells via PRDX2, alleviating age-related diseases like cancer and Alzheimer's.

This study identifies SONAVP neuron hyperactivity as a driver of aging-related homeostatic deficits and suggests AVP signaling modulation as a therapeutic strategy.

This study presents a longitudinal assessment of age-related changes in Brown-Norway rat physiology and histopathology at 6, 17, and 27 months of age to provide healthspan parameters for aging research.

This study shows that senescent bone cells' secretome causes spatially varied ECM changes and mechanical weakness in human brain organoids.

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

This study identifies apigenin as a senomorphic agent that modulates the senescence-associated secretory phenotype (SASP) to improve aging-related outcomes.

This study shows bisphosphonates reduce senescence markers and alter proteomes in multiple cell types, suggesting anti-ageing effects beyond bone health.

This study investigates time-dependent changes in osteocyte cytoskeleton mechanics and morphology due to senescence-associated secretory phenotype factors, identifying biophysical markers for senescent osteocytes.

This study identifies time-dependent mechanical changes in senescent osteocytes, linking them to impaired mechanosensation and bone fragility.

The paper profiles miRNA expression during senescence and aging to identify potential circulating biomarkers of senescent cell burden in mice and humans.

The paper shows that partial inhibition of mitochondrial complex I protects against neurodegeneration in Alzheimer's mice by improving energy homeostasis, synaptic function, and reducing inflammation.

This study investigates the effects of dasatinib plus quercetin on uterine fibrosis in aged mice, showing increased p53 expression and reduced miR34a levels.