Joshua J. Breunig

Dynamin 2–dependent endocytosis differentially regulates ligand and receptor contributions to Notch signaling during neural precursor cell fate determination

This study shows that dynamin 2 is essential for neural stem cell maintenance through its role in endocytosis, which differentially regulates Notch ligand and receptor activity.

The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits

This study identifies SONAVP neuron hyperactivity as a driver of aging-related homeostatic deficits and suggests AVP signaling modulation as a therapeutic strategy.

Cholinergic Neuronal Activity Promotes Diffuse Midline Glioma Growth through Muscarinic Signaling

This study shows that cholinergic neuron activity promotes both healthy OPC and DMG proliferation through muscarinic receptors, with specific nuclei driving growth in different brain regions.

Generating in vivo somatic mouse mosaics with locus-specific, stably-integrated transgenic elements

The paper introduces MADR, a method to generate somatic mosaics in mice with precise control over transgene integration and zygosity, and demonstrates its use in creating glioma models.