Cell crowding activates pro-invasive mechanotransduction pathway in high-grade DCIS via TRPV4 inhibition and cell volume reduction
Xiangning Bu, Nathanael Ashby, Teresa Vitali, Sulgi Lee, Ananya Gottumukkala, Kangsun Yun, Sana O. Tabbara, Patricia S. Latham, Christine B. Teal, Inhee Chung
This study shows cell crowding promotes invasion in high-grade DCIS by reducing cell volume through TRPV4 inhibition and mechanotransduction.
eLife · Sep 26, 2024Peer-reviewedCell Biology