Chromatin topology control by a muscle-specific ribosomal protein
Makoto Nakamura, Xiaoxin Chen, Shun Yao, Lynette Xin Chan, Ruan Hongmei, Alexis Boulinguiez, Nav Lally, Hao Wu, Kara Kodani, Kentaro Hirose, James P. Pirruccello, Alberto Malerba, Yifan Cheng, Vasanth Vedantham, Longzhi Tan, , Guo N. Huang
This study identifies Rpl3l as a muscle-specific ribosomal protein that regulates chromatin insulation in atrial cardiomyocytes, linking genome structure to cardiac rhythm stability.
bioRxiv · Jun 26, 2026 · PreprintPhysiology