Jeffrey E. Olgin

This study identifies Rpl3l as a muscle-specific ribosomal protein that regulates chromatin insulation in atrial cardiomyocytes, linking genome structure to cardiac rhythm stability.

This study shows that primary cilia in cardiac fibroblasts promote fibrosis and impair heart function after myocardial infarction by amplifying fibrotic signaling.

This study creates a gene regulation map of the human fetal heart to interpret genetic variants associated with congenital heart disease and cardiac traits, identifying valvular interstitial cells as key regulators.

The paper uses single-nucleus RNA/ATAC-seq to analyze HCM mouse models and identifies differences in gene expression and signaling pathways between mutant and wild-type hearts.