12-Lipoxygenase (12-LOX) Plays a Key Role in Hyperinflammatory Response Caused by SARS-CoV-2
Melinee D’silva, Karen Jackson, Matthew T. Vaughan, David J. Maloney, Sachin A. Gupte, Jerry L. Nadler, Chandra Shekhar Bakshi
This study identifies 12-LOX as a key driver of hyperinflammatory response in severe COVID-19 and shows that its inhibition with VLX-1005 improves survival and reduces inflammation in mice.
mBio · Apr 30, 2026Peer-reviewedMicrobiology