This study identifies 12-LOX as a key driver of hyperinflammatory response in severe COVID-19 and shows that its inhibition with VLX-1005 improves survival and reduces inflammation in mice.

mBio · Apr 30, 2026Peer-reviewedMicrobiology

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice

Kerim B. Kaylan, Titli Nargis, Kayla T. Figatner, Jiayi E. Wang, Sarida Pratuangtham, Advaita Chakraborty, Isabel Casimiro, Jerry L. Nadler, Matthew B. Boxer, David J. Maloney, Ryan M. Anderson, Raghavendra G. Mirmira, Sarah A. Tersey

This study shows that inhibiting 12-LOX improves glucose homeostasis and reduces obesity-related inflammation in human gene replacement mice.

bioRxiv · Jan 10, 2025 · PreprintPhysiology

12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice

Titli Nargis, Charanya Muralidharan, Jacob R. Enriquez, Jiayi E. Wang, Kerim B. Kaylan, Advaita Chakraborty, Sarida Pratuangtham, Kayla T. Figatner, Jennifer B. Nelson, Sarah C. May, Jerry L. Nadler, Matthew B. Boxer, David J. Maloney, Sarah A. Tersey, Raghavendra G. Mirmira

This study shows that inhibiting 12-LOX with VLX-1005 delays autoimmune diabetes onset in human gene replacement mice by altering inflammatory pathways and immune cell infiltration.

JCI Insight · Nov 12, 2024Peer-reviewedMolecular Biology