Author

Sachin A. Gupte

New York Medical CollegeORCID 0000-0001-7453-8303Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Chandra Shekhar BakshiiD· 1 shared David J. MaloneyiD· 1 shared Jerry L. NadleriD· 1 shared Karen Jackson· 1 shared Matthew T. Vaughan· 1 shared Melinee D’silvaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperMicrobiology

Chandra Shekhar BakshiORCID

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1 paper

Recent·Most cited

MicrobiologymBioPeer-reviewedApr 30, 2026

12-Lipoxygenase (12-LOX) Plays a Key Role in Hyperinflammatory Response Caused by SARS-CoV-2

Melinee D’silva, Karen Jackson, Matthew T. Vaughan…·Chandra Shekhar Bakshi

This study identifies 12-LOX as a key driver of hyperinflammatory response in severe COVID-19 and shows that its inhibition with VLX-1005 improves survival and reduces inflammation in mice.

DOI 10.1128/mbio.00738-26

mouseexperimental assay

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