Chandra Shekhar Bakshi

This study shows that F. tularensis modulates the macrophage redox environment to suppress Aim2 inflammasome activation, revealing a mechanism by which it evades host immune responses.

This study identifies FTL_0690 as an acyl-CoA synthetase critical for lipid homeostasis, membrane integrity, and oxidative stress resistance in F. tularensis LVS.

This study identifies 12-LOX as a key driver of hyperinflammatory response in severe COVID-19 and shows that its inhibition with VLX-1005 improves survival and reduces inflammation in mice.

This study investigates the role of thioredoxin reductase (TrxB) in oxidative stress resistance and intramacrophage survival in Francisella tularensis.