Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation
Ivana Petrovska, Elisabeth Nüske, Matthias C Munder, Gayathrie Kulasegaran, Liliana Malinovska, Sonja Kroschwald, Doris Richter, Karim Fahmy, Kimberley Gibson, Jean-Marc Verbavatz, Simon Alberti
The paper shows that metabolic enzymes like glutamine synthetase form filaments at low pH during starvation, leading to inactivation and storage, suggesting a general mechanism for cellular adaptation to starvation.
bioRxiv · Apr 11, 2014Cell Biology