Lineage of origin-specific developmental programs drive the behaviors of malignant cells in an avian embryo model of human Medulloblastoma subgroups
Marion Mallet, Florian Martin, Karine Thoinet, Caroline Imbert, Moein Sarhadi, Jérémy Ganofsky, Jacob Torrejon-Diaz, Tanguy Fenouil, Céline Delloye‐Bourgeois, Julien Falk, Cécile Faure‐Conter, Ludovic Telley, David Meyronet, Olivier Ayrault, Valérie Castellani, Servane Tauszig-Delamasure
The paper investigates how the developmental lineage of medulloblastoma cells influences their behavior in an avian embryo model, finding that G3 tumors use SLIT signaling linked to aggressiveness.
bioRxiv · Oct 9, 2025 · PreprintCancer Biology