Olivier Ayrault

This study identifies RBFOX2 as a suppressor of oncogenic cell plasticity in Group 3 medulloblastoma by regulating alternative splicing and cytoskeletal dynamics.

This study identifies metabolic partnerships between medulloblastoma and macrophages that drive leptomeningeal metastases and suggests targeting the CXCL12-SCARB1-cholesterol axis as a therapeutic strategy.

The paper identifies functionally distinct ALK and ROS1 fusions in infant-type hemispheric gliomas, showing they converge on STAT3 and SHP2 activation through different mechanisms.

The paper investigates how the developmental lineage of medulloblastoma cells influences their behavior in an avian embryo model, finding that G3 tumors use SLIT signaling linked to aggressiveness.

This study identifies RREB1 as a key driver of Group 3 medulloblastoma, showing its role in tumor growth and survival through the c-MET signaling pathway.

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.