Valérie Castellani

This study identifies LRRTM4 as a coordinator of cell migration through interactions with glypicans in developing cortex and cancer cells.

The paper investigates how the developmental lineage of medulloblastoma cells influences their behavior in an avian embryo model, finding that G3 tumors use SLIT signaling linked to aggressiveness.

This study shows that motor nerves guide the development of sympathetic ganglia by directing the migration and differentiation of neural crest-derived sympathoblasts.

The paper identifies ATP1A3's role in spinal circuit development by showing its requirement for axon pathfinding and EF alignment in both human and chicken models.

This study shows that axon guidance defects prevent functional recovery in CNS regeneration and that suppressing Slit/Robo signaling enables axons to reinnervate the SCN, leading to behavioral recovery.

This study determines the structure of the GPC3-Unc5D complex and shows its role in guiding neuronal and cancer cell migration.

The paper identifies CSF-delivered Semaphorin complexes that regulate apical progenitor dynamics in the developing neocortex through distinct signaling pathways.

The paper shows that SlitC-PlxnA1 signaling limits growth cone exploration to ensure forward midline navigation, not post-crossing barrier mechanisms.

The paper investigates how commissural axons develop sensitivity to midline repellents through receptor dynamics during navigation, revealing spatial and temporal receptor profiles that enable discrimination of repulsive signals.