Author

Karly C. Sourris

Baker Heart and Diabetes Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 1

Frequent Co-Authors

Aowen ZhuangiD· 2 shared Benjamin Luke SchulziD· 2 shared Domenica A. McCarthy· 2 shared Felicia Y. T. Yap· 2 shared Josephine Maree ForbesiD· 2 shared Melinda T. CoughlaniD· 2 shared Sally A. Penfold· 2 shared Brooke E. HarcourtiD· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Aowen ZhuangORCID

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2 papers

Recent·Most cited

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion.

Aowen Zhuang, Felicia Y. T. Yap, Domenica A. McCarthy, Sherman S. Leung, Sally A. Penfold, Chris Leung, Karly C. Sourris, Brooke E. Harcourt, Vicki Thallas‐Bonke, Melinda T. Coughlan, Benjamin Luke Schulz, Josephine Maree Forbes

This study shows that increasing OST48 expression in diabetic mice improves insulin secretion but does not prevent diabetic kidney disease despite enhancing AGE clearance.

Scientific Reports · Sep 20, 2019Peer-reviewedMolecular Biology

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion in experimental diabetic kidney disease via promotion of endoplasmic reticulum stress

Aowen Zhuang, Felicia Y. T. Yap, Domenica A. McCarthy, Sally A. Penfold, Karly C. Sourris, Melinda T. Coughlan, Benjamin Luke Schulz, Josephine Maree Forbes

This study shows that increased podocyte expression of oligosaccharyltransferase-48kDa subunit worsens diabetic kidney disease by causing endoplasmic reticulum stress and kidney dysfunction.

bioRxiv · Jul 22, 2019 · PreprintMolecular Biology