Josephine Maree Forbes

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion.

This study shows that increasing OST48 expression in diabetic mice improves insulin secretion but does not prevent diabetic kidney disease despite enhancing AGE clearance.

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion in experimental diabetic kidney disease via promotion of endoplasmic reticulum stress

This study shows that increased podocyte expression of oligosaccharyltransferase-48kDa subunit worsens diabetic kidney disease by causing endoplasmic reticulum stress and kidney dysfunction.

Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue

The paper identifies a nuclear RAGE isoform in kidney tissue that binds to its own gene promoter, suggesting self-regulation of RAGE expression, which is altered in obesity and kidney disease.