Author

Sally A. Penfold

Baker Heart and Diabetes Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Josephine Maree ForbesiD· 3 shared Melinda T. CoughlaniD· 3 shared Aowen ZhuangiD· 2 shared Benjamin Luke SchulziD· 2 shared Brooke E. HarcourtiD· 2 shared Domenica A. McCarthy· 2 shared Felicia Y. T. Yap· 2 shared Karly C. Sourris· 2 shared

Activity by Year

2019-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMolecular Biology

Josephine Maree ForbesORCID

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3 papers

Recent·Most cited

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion.

Aowen Zhuang, Felicia Y. T. Yap, Domenica A. McCarthy, Sherman S. Leung, Sally A. Penfold, Chris Leung, Karly C. Sourris, Brooke E. Harcourt, Vicki Thallas‐Bonke, Melinda T. Coughlan, Benjamin Luke Schulz, Josephine Maree Forbes

This study shows that increasing OST48 expression in diabetic mice improves insulin secretion but does not prevent diabetic kidney disease despite enhancing AGE clearance.

Scientific Reports · Sep 20, 2019Peer-reviewedMolecular Biology

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion in experimental diabetic kidney disease via promotion of endoplasmic reticulum stress

Aowen Zhuang, Felicia Y. T. Yap, Domenica A. McCarthy, Sally A. Penfold, Karly C. Sourris, Melinda T. Coughlan, Benjamin Luke Schulz, Josephine Maree Forbes

This study shows that increased podocyte expression of oligosaccharyltransferase-48kDa subunit worsens diabetic kidney disease by causing endoplasmic reticulum stress and kidney dysfunction.

bioRxiv · Jul 22, 2019 · PreprintMolecular Biology

Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue

Brooke E. Harcourt, Aaron McClelland, Hiroshi Yamamoto, Hideto Yonekura, Yasuhiko Yamamoto, Sally A. Penfold, Amelia K. Fotheringham, David Alan Vesey, David Wayne Johnson, Melinda T. Coughlan, Mark Emmanuel Cooper, Phillip Kantharidis, Josephine Maree Forbes

The paper identifies a nuclear RAGE isoform in kidney tissue that binds to its own gene promoter, suggesting self-regulation of RAGE expression, which is altered in obesity and kidney disease.

bioRxiv · May 9, 2019 · PreprintMolecular Biology