Author

Brooke E. Harcourt

Translational Research InstituteORCID 0000-0003-0028-873XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Josephine Maree ForbesiD· 2 shared Melinda T. CoughlaniD· 2 shared Sally A. Penfold· 2 shared Aaron McClellandiD· 1 shared Amelia K. FotheringhamiD· 1 shared Aowen ZhuangiD· 1 shared Benjamin Luke SchulziD· 1 shared Chris LeungiD· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Josephine Maree ForbesORCID

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2 papers

Recent·Most cited

Molecular BiologyScientific ReportsPeer-reviewedSep 20, 2019

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion.

Aowen Zhuang, Felicia Y. T. Yap, Domenica A. McCarthy…·Josephine Maree Forbes

This study shows that increasing OST48 expression in diabetic mice improves insulin secretion but does not prevent diabetic kidney disease despite enhancing AGE clearance.

6 citations

mouseexperimental assay

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Molecular BiologybioRxivPreprintMay 9, 2019

Nuclear Expression and DNA Binding Capacity of Receptor for Advanced Glycation End Products in Renal Tissue

Brooke E. Harcourt, Aaron McClelland, Hiroshi Yamamoto…·Josephine Maree Forbes

The paper identifies a nuclear RAGE isoform in kidney tissue that binds to its own gene promoter, suggesting self-regulation of RAGE expression, which is altered in obesity and kidney disease.

DOI 10.1101/632596

mousehuman

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