Melinda T. Coughlan

This study profiles bioenergetic changes in fresh human kidney tissue from diabetic patients with preserved function, revealing compensatory metabolic adaptation and intrinsic mitochondrial dysfunction.

This study shows that an AGE-rich diet during adolescence impairs memory via hippocampal synaptic deficits and microbiome changes, which can be mitigated by AGE inhibitors.

This study investigates the role of GPR109a in diabetic nephropathy by examining its effects on renal injury and intestinal permeability in Gpr109a-/- mice.

This study shows that increasing OST48 expression in diabetic mice improves insulin secretion but does not prevent diabetic kidney disease despite enhancing AGE clearance.

This study shows that increased podocyte expression of oligosaccharyltransferase-48kDa subunit worsens diabetic kidney disease by causing endoplasmic reticulum stress and kidney dysfunction.

The paper identifies a nuclear RAGE isoform in kidney tissue that binds to its own gene promoter, suggesting self-regulation of RAGE expression, which is altered in obesity and kidney disease.