Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis
Timm O. Koller, Max J. Berger, Martino Morici, Helge Paternoga, Timur M. Bulatov, Adriana Di Stasi, Tam Dang, Andi Mainz, Karoline Raulf, Caillan Crowe‐McAuliffe, Marco Scocchi, Mario Mardirossian, Bertrand Beckert, Nora Vázquez‐Laslop, Alexander S. Mankin, , Daniel N. Wilson
This study determines the structure of paenilamicin PamB2 bound to stalled ribosomes, revealing its mechanism as a context-specific translocation inhibitor of protein synthesis.
Nature Chemical Biology · Oct 17, 2024Peer-reviewedBiochemistry