Martino Morici

The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation

This study determines the structures of 30S initiation complexes inhibited by kasugamycin, edeine, and GE81112, revealing distinct mechanisms of action within the E-site.

Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis

This study determines the structure of paenilamicin PamB2 bound to stalled ribosomes, revealing its mechanism as a context-specific translocation inhibitor of protein synthesis.