Alexander S. Mankin

Structural modification of oxazolidinone antibiotics alters nascent peptide stalling preference and peptide trajectory through the ribosome

This study shows that structural modifications of oxazolidinone antibiotics alter their preference for specific penultimate amino acids during translation inhibition.

Sequence-specific trapping of EF-Tu/glycyl-tRNA complex on the ribosome by bottromycin

This study identifies bottromycin's mechanism of action as selectively trapping EF-Tu/glycyl-tRNA complex on the ribosome, inhibiting translation at glycine codons.

Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis

This study determines the structure of paenilamicin PamB2 bound to stalled ribosomes, revealing its mechanism as a context-specific translocation inhibitor of protein synthesis.

Inhibition of translation termination by Drosocin, an antimicrobial peptide from fruit flies

This study identifies Drosocin as a type II PrAMP that inhibits protein synthesis termination by stalling ribosomes at stop codons, distinct from apidaecin.

Retapamulin-assisted ribosome profiling reveals the alternative bacterial proteome

The paper uses retapamulin-assisted ribosome profiling to identify alternative translation start sites in E. coli, revealing new proteins and regulatory roles.