Author

Helge Paternoga

Universität HamburgORCID 0000-0001-8335-3239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Daniel N. WilsoniD· 3 shared Martino MoriciiD· 2 shared Adriana Di StasiiD· 1 shared Agnieszka A. Pochopien· 1 shared Alexander S. MankiniD· 1 shared Ana Elena Sanchez-CastroiD· 1 shared Andi MainziD· 1 shared Andrea DallapèiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiochemistry

Daniel N. WilsonORCID

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3 papers

Recent·Most cited

The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation

Haaris Ahsan Safdari, Martino Morici, Ana Elena Sanchez-Castro, Andrea Dallapè, Helge Paternoga, Anna Maria Giuliodori, Attilio Fabbretti, Pohl Milón, Daniel N. Wilson

This study determines the structures of 30S initiation complexes inhibited by kasugamycin, edeine, and GE81112, revealing distinct mechanisms of action within the E-site.

Nature Communications · Mar 12, 2025Peer-reviewedBiochemistry

Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis

Timm O. Koller, Max J. Berger, Martino Morici, Helge Paternoga, Timur M. Bulatov, Adriana Di Stasi, Tam Dang, Andi Mainz, Karoline Raulf, Caillan Crowe‐McAuliffe, Marco Scocchi, Mario Mardirossian, Bertrand Beckert, Nora Vázquez‐Laslop, Alexander S. Mankin, , Daniel N. Wilson

This study determines the structure of paenilamicin PamB2 bound to stalled ribosomes, revealing its mechanism as a context-specific translocation inhibitor of protein synthesis.

Nature Chemical Biology · Oct 17, 2024Peer-reviewedBiochemistry

The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys> isoacceptors in the P site

Kathryn Jane Turnbull, Helge Paternoga, Esther von der Weth, Artyom A. Egorov, Agnieszka A. Pochopien, Yujie Zhang, Lilit Nersisyan, Tõnu Margus, Marcus Johansson, Vicent Pelechano, Daniel N. Wilson, Vasili Hauryliuk

Nucleic Acids Research · Sep 1, 2024Peer-reviewedMolecular Biology