Bertrand Beckert

Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis

This study determines the structure of paenilamicin PamB2 bound to stalled ribosomes, revealing its mechanism as a context-specific translocation inhibitor of protein synthesis.

DNA-measuring Wadjet SMC ATPases restrict smaller circular plasmids by DNA cleavage.

The paper shows JetABCD SMC complexes restrict small circular plasmids by cleaving them, while linear plasmids are not restricted, and presents a structural model for this process.

eEF3 promotes late stages of tRNA translocation on the ribosome

This study identifies eEF3's role in promoting tRNA dissociation from the E site during translation elongation in fungi, revealing structural insights into the yeast translation cycle.

ResQ, a release factor-dependent ribosome rescue factor in the Gram-positive bacterium Bacillus subtilis

The paper identifies ResQ as a release factor-dependent ribosome rescue factor in Bacillus subtilis, showing it is essential for growth and functions by recruiting RF2 to stalled ribosomes.

Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1

The paper presents cryo-EM structures of hibernating 70S and 100S ribosomes from E. coli, revealing the roles of HPF and RMF in ribosome inactivation and dimerization.