Rab11FIP2 controls NLRP3 inflammasome activation through Rab11b
Caroline Gravastrand, Maria Yurchenko, Stine Kristensen, Astrid Skjesol, Carmen Chen, Zunaira Iqbal, Karoline Ruud Dahlen, Unni Nonstad, Liv Ryan, Terje Espevik, Harald Husebye
This study shows Rab11-FIP2 and Rab11b regulate NLRP3 inflammasome activation in human macrophages by controlling caspase-1 cleavage, pyroptosis, and NLRP3 translocation to the trans-Golgi network.
bioRxiv · May 19, 2025 · PreprintImmunology