Liv Ryan

Cell-intrinsic complement C3 suppresses IFN-β production in macrophages

This study shows that cell-intrinsic complement C3 suppresses IFN-β production in macrophages by limiting IRF3-TBK1 complex formation.

SLAMF1-peptide mediated epigenetic priming reprograms innate immune responses in sepsis

This study identifies P7-Pen as a peptide that enhances monocyte inflammatory responses in sepsis by modulating histone acetylation through ABHD14B.

NINJ1 mediates necrosis of Mycobacterium tuberculosis infected human macrophages

This study identifies NINJ1 as a mediator of plasma membrane rupture in Mtb-infected macrophages, showing it operates independently of canonical cell death pathways and requires the ESX-1 secretion system.

A novel TIRAP-MyD88 inhibitor blocks TLR7- and TLR8-induced type I IFN responses

This study identifies a peptide that inhibits TLR7- and TLR8-induced type I IFN responses by disrupting TIRAP-MyD88 interaction, with species-specific effects observed.

Rab11FIP2 controls NLRP3 inflammasome activation through Rab11b

This study shows Rab11-FIP2 and Rab11b regulate NLRP3 inflammasome activation in human macrophages by controlling caspase-1 cleavage, pyroptosis, and NLRP3 translocation to the trans-Golgi network.

Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation

This study identifies a SLAMF1-derived peptide, P7N4, that induces apoptosis in multiple myeloma cells by degrading IRF4, enhancing chemotherapy efficacy and showing minimal toxicity to healthy cells.

Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance

This study identifies Raver1 as a regulator of Ripk1 RNA splicing, which affects caspase-8-mediated pyroptosis, inflammation, and resistance to Yersinia infection.