Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model
Deanna M. Marchionini, Jeh-Ping Liu, Alberto Ambesi‐Impiombato, Kimberly Kerker, Kim Cirillo, Mukesh Bansal, Rich Mushlin, Daniela Brunner, Sylvie Ramboz, Mei Yee Kwan, Kirsten Kuhlbrodt, Karsten Tillack, Finn Peters, Leena Rauhala, John C. Obenauer, , Scott O. Zeitlin
This study shows that moderate global lowering of mutant Huntingtin in a HD mouse model delays some deficits but benefits diminish over time, suggesting long-term mHtt lowering may be needed for sustained benefit.
JCI Insight · Oct 23, 2022Peer-reviewedNeuroscience