Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes
Maike Kosanke, Katarzyna Osetek, Alexandra Haase, Lutz Wiehlmann, Colin Davenport, Adrian Schwarzer, Felix F. Adams, Marc‐Jens Kleppa, Axel Schambach, Sylvia Merkert, Stephanie Wunderlich, Sandra Menke, Marie Dorda, Ulrich Martin
The paper shows that reprogramming enriches for mutations in cancer-associated genes in hiPSCs, potentially increasing tumor risk.
Molecular Therapy · Apr 5, 2021Peer-reviewedGenomics