Author

Marie Dorda

Medizinische Hochschule Hannover

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Colin DavenportiD· 2 shared Lutz Wiehlmann· 2 shared Maike KosankeiD· 2 shared Ulrich MartiniD· 2 shared Adrian SchwarzeriD· 1 shared Alexandra HaaseiD· 1 shared Anna Melchert· 1 shared Axel SchambachiD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Colin DavenportORCID

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2 papers

Recent·Most cited

iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome

Maike Kosanke, Colin Davenport, Mónika Szepes, Lutz Wiehlmann, Tim Kohrn, Marie Dorda, Jonas Gruber, Kaja S. Menge, Maike Sievert, Anna Melchert, Ina Gruh, Gudrun Göhring, Ulrich Martin

The paper analyzes mtDNA variants in iPSCs and finds that culture expansion selects against harmful mitochondrial mutations, while reprogramming and differentiation do not significantly alter mtDNA heteroplasmy.

Stem Cell Reports · Sep 23, 2021Peer-reviewedGenomics

Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes

Maike Kosanke, Katarzyna Osetek, Alexandra Haase, Lutz Wiehlmann, Colin Davenport, Adrian Schwarzer, Felix F. Adams, Marc‐Jens Kleppa, Axel Schambach, Sylvia Merkert, Stephanie Wunderlich, Sandra Menke, Marie Dorda, Ulrich Martin

The paper shows that reprogramming enriches for mutations in cancer-associated genes in hiPSCs, potentially increasing tumor risk.

Molecular Therapy · Apr 5, 2021Peer-reviewedGenomics