Maike Kosanke

Human ILC methylomes uncover stable lineage codes and disease-linked ILC2 regulators in allergy

This study maps DNA methylation patterns in human ILC subsets, identifies disease-linked regulators in ILC2, and shows their role in allergic inflammation.

iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome

The paper analyzes mtDNA variants in iPSCs and finds that culture expansion selects against harmful mitochondrial mutations, while reprogramming and differentiation do not significantly alter mtDNA heteroplasmy.

Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes

The paper shows that reprogramming enriches for mutations in cancer-associated genes in hiPSCs, potentially increasing tumor risk.