Author

Lutz Wiehlmann

Medizinische Hochschule Hannover

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioinformatics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 2 Assay:metagenomics· 2 Research Focus:variant calling· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Colin DavenportiD· 4 shared Maike KosankeiD· 2 shared Marie Dorda· 2 shared Ulrich MartiniD· 2 shared Adrian SchwarzeriD· 1 shared Alexandra Burkert· 1 shared Alexandra HaaseiD· 1 shared Andreas LeffleriD· 1 shared

Activity by Year

2021-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersGenomics

Colin DavenportORCID

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Author profile →

5 papers

Recent·Most cited

Post-Weaning Gut Microbiota Colonization Reveals Divergent Recovery of Skeletal Muscle and Peripheral Nerves

Sonia Calabrò, Davide PELLEGRINO, Chiara Cicconetti, Svenja Kankowski, Sajjad Farzin, Francesca Bertone, Mira Frühwein, Francesca Anselmi, Dario Bizzotto, Marijana Basic, Silvia Bolsega, Matthias Steglich, Lutz Wiehlmann, Cecilia Gelfi, Daniele Capitanio, , Giulia Ronchi

This study shows that post-weaning gut microbiota colonization partially restores skeletal muscle but not peripheral nerve abnormalities in germ-free mice.

bioRxiv · Sep 14, 2026 · PreprintNeuroscience

Wochenende - modular and flexible alignment-based shotgun metagenome analysis

Ilona Rosenboom, Tobias Scheithauer, Fabian C. Friedrich, Sophia Pörtner, Lisa Hollstein, Marie‐Madlen Pust, Konstantinos Sifakis, Tom Wehrbein, Bodo Rosenhahn, Lutz Wiehlmann, Patrick Chhatwal, Burkhard Tümmler, Colin Davenport

Wochenende is a modular pipeline for shotgun metagenome analysis that improves alignment filtering and visualization for microbial taxonomy and functional gene analysis.

BMC Genomics · Nov 11, 2022Peer-reviewedBioinformatics

iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome

Maike Kosanke, Colin Davenport, Mónika Szepes, Lutz Wiehlmann, Tim Kohrn, Marie Dorda, Jonas Gruber, Kaja S. Menge, Maike Sievert, Anna Melchert, Ina Gruh, Gudrun Göhring, Ulrich Martin

The paper analyzes mtDNA variants in iPSCs and finds that culture expansion selects against harmful mitochondrial mutations, while reprogramming and differentiation do not significantly alter mtDNA heteroplasmy.

Stem Cell Reports · Sep 23, 2021Peer-reviewedGenomics

MinION nanopore sequencing provides similar methylation estimates to Sanger bisulfite sequencing in the TRPA1 promoter region

Sara Gombert, Kirsten Jahn, Hansi Pathak, Alexandra Burkert, Gunnar Schmidt, Lutz Wiehlmann, Colin Davenport, Björn Brändl, Frank Ulrich Müller, Andreas Leffler, Maximilian Deest, Helge Frieling

bioRxiv · Sep 17, 2021 · PreprintMolecular Biology

Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes

Maike Kosanke, Katarzyna Osetek, Alexandra Haase, Lutz Wiehlmann, Colin Davenport, Adrian Schwarzer, Felix F. Adams, Marc‐Jens Kleppa, Axel Schambach, Sylvia Merkert, Stephanie Wunderlich, Sandra Menke, Marie Dorda, Ulrich Martin

The paper shows that reprogramming enriches for mutations in cancer-associated genes in hiPSCs, potentially increasing tumor risk.

Molecular Therapy · Apr 5, 2021Peer-reviewedGenomics