Author

Sylvia Merkert

Medizinische Hochschule HannoverORCID 0000-0001-7275-4205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alexandra HaaseiD· 2 shared Stephanie Wunderlich· 2 shared Ulrich MartiniD· 2 shared Adrian SchwarzeriD· 1 shared André ZeugiD· 1 shared Andreas KirschningiD· 1 shared Andreas Martens· 1 shared Axel SchambachiD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Alexandra HaaseORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 19, 2021

Targeted biallelic integration of an inducible Caspase 9 suicide gene for safer cellular therapies prevents development of drug-resistant escapees in human iPSCs

Stephanie Wunderlich, Alexandra Haase, Sylvia Merkert…·Ulrich Martin

This study introduces a biallelic inducible Caspase9 suicide gene system in hiPSCs to prevent drug-resistant escapees, showing no escapees in biallelic cells versus rare escapees in monoallelic cells.

DOI 10.1101/2021.09.19.460940

humanexperimental assay

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GenomicsMolecular TherapyPeer-reviewedApr 5, 2021

Reprogramming enriches for somatic cell clones with small scale mutations in cancer-associated genes

Maike Kosanke, Katarzyna Osetek, Alexandra Haase…·Ulrich Martin

The paper shows that reprogramming enriches for mutations in cancer-associated genes in hiPSCs, potentially increasing tumor risk.

19 citations

humanwhole-exome sequencing

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