Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
Joanna R. Thomas, Kate M. Moore, Caroline Sproat, Horacio J. Maldonado-Lorca, Stephanie Mo, Syed Haider, Dean Hammond, Gareth J. Thomas, Ian A. Prior, Pedro R. Cutillas, Louise J. Jones, John F. Marshall, Mark R. Morgan
This study shows that Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and drives breast cancer invasion by coordinating matrix stiffness and transcriptional reprogramming.
bioRxiv · Sep 4, 2018 · PreprintCancer Biology