Author

John F. Marshall

Queen Mary University of LondonORCID 0000-0002-0494-2295Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 4 Organism:mouse· 3 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Eleni ManiatiiD· 2 shared Gareth J. ThomasiD· 2 shared Guillem FuertesiD· 2 shared Albert HenryiD· 1 shared Alejandro Martin-TrujilloiD· 1 shared Alex William HewittiD· 1 shared Amandine C. TaniD· 1 shared Amy MiniteriD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Eleni ManiatiORCID

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Author profile →

5 papers

Recent·Most cited

Tandem repeat variation shapes immune cell type-specific gene expression

Hope A. Tanudisastro, Anna S. E. Cuomo, Ben Weisburd, Matthew J. Welland, Eleanor Spenceley, Michael Franklin, Angli Xue, Hao Lawrence Huang, Blake Bowen, Jianan Fan, Oscar A. Dong, Albert Henry, Peter C. Allen, Kristof Wing, Owen Tang, , Daniel G. MacArthur

The paper identifies immune cell type-specific gene expression regulated by tandem repeats using multi-omics data from large cohorts.

Nature · Oct 28, 2026Peer-reviewedGenomics

Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer

Florian Laforêts, Panoraia Kotantaki, Samar Elorbany, Joseph Hartlebury, Joash Dominic Joy, Beatrice Malacrida, Rachel C Bryan-Ravenscroft, Chiara Berlato, Erica Di Federico, John F. Marshall, Ranjit Manchanda, Wolfgang Jarolimek, Lara Perryman, Eleni Maniati, Frances R. Balkwill

The paper shows that modifying the tumor microenvironment's extracellular matrix improves chemotherapy response in ovarian cancer models.

iScience · Feb 9, 2026Peer-reviewedCancer Biology

Ephrin inhibition disrupts stromal-cancer crosstalk and reduces metastasis in pancreatic cancer

Cerian L. Bolton, Rhianna O’Sullivan, Guillem Fuertes, Francis Sprouse, Hanghang Wang, Shinelle Menezes, Amandine C. Tan, Sabrina Simoncelli, Angus J.M. Cameron, John F. Marshall, Mark J. Henkemeyer, Edward P. Carter, Richard Philip Grose

This study shows that inhibiting Ephrin signaling disrupts stromal-cancer interactions and reduces metastasis in pancreatic cancer using mouse models.

bioRxiv · Dec 13, 2025 · PreprintCancer Biology

Pancreatic cancer metastasis is regulated by an eleven amino-acid sequence

Guillem Fuertes, Daniele Di Biagio, Riddhi P Sontakke, Eleni Maniati, Benjamin H. Jenkins, Gareth J. Thomas, John F. Marshall

This study identifies an 11-amino-acid sequence in the integrin β6 subunit that regulates pancreatic cancer metastasis by affecting cell proliferation, migration, and invasion.

bioRxiv · Dec 10, 2025 · PreprintCancer Biology

Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion

Joanna R. Thomas, Kate M. Moore, Caroline Sproat, Horacio J. Maldonado-Lorca, Stephanie Mo, Syed Haider, Dean Hammond, Gareth J. Thomas, Ian A. Prior, Pedro R. Cutillas, Louise J. Jones, John F. Marshall, Mark R. Morgan

This study shows that Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and drives breast cancer invasion by coordinating matrix stiffness and transcriptional reprogramming.

bioRxiv · Sep 4, 2018 · PreprintCancer Biology