Epigenome priming dictates transcription response and white matter fate upon perinatal inflammation
Anne‐Laure Schang, Juliette Van Steenwinckel, Zoi S. Ioannidou, Julia Lipecki, Charlotte Rich‐Griffin, Kate Woolley-Allen, Nigel P. Dyer, Tifenn Le Charpentier, Patrick Schäfer, Bobbi Fleiss, Sascha Ott, Délara Sabéran‐Djoneidi, Valérie Mezger, Pierre Gressèns
The paper shows that neuroinflammation in OPCs causes major transcriptomic changes by exploiting a primed epigenetic landscape rather than altering chromatin accessibility, leading to white matter injury.
Cell Death and Disease · Dec 13, 2022Peer-reviewedDevelopmental Biology