Author

Anne‐Laure Schang

Centre National de la Recherche ScientifiqueORCID 0000-0003-1712-8505Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bobbi FleissiD· 3 shared Juliette Van SteenwinckeliD· 3 shared Pierre GressènsiD· 3 shared Tifenn Le Charpentier· 3 shared Alka SaxenaiD· 2 shared Gareth BalliD· 2 shared A David Edwards· 1 shared Amélie Montané· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersDevelopmental Biology

Bobbi FleissORCID

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3 papers

Recent·Most cited

Developmental BiologyCell Death and DiseasePeer-reviewedDec 13, 2022

Epigenome priming dictates transcription response and white matter fate upon perinatal inflammation

Anne‐Laure Schang, Juliette Van Steenwinckel, Zoi S. Ioannidou…·Pierre Gressèns

The paper shows that neuroinflammation in OPCs causes major transcriptomic changes by exploiting a primed epigenetic landscape rather than altering chromatin accessibility, leading to white matter injury.

18 citations

mousebulk RNA-seq

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ImmunologybioRxivPreprintMay 31, 2018

Loss of the Wnt/β-catenin pathway in microglia of the developing brain drives pro-inflammatory activation leading to white matter injury

Juliette Van Steenwinckel, Anne-Laure Schang, Michelle L Krishnan…·Pierre Gressens

The paper shows that reduced Wnt/β-catenin signaling in microglia of the developing brain causes pro-inflammatory activation and white matter injury, and that restoring this pathway can prevent these effects.

DOI 10.1101/334359

humanbulk RNA-seq

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GenomicsNature CommunicationsPeer-reviewedAug 30, 2017

Integrative genomics study of microglial transcriptome reveals effect of DLG4 (PSD95) on white matter in preterm infants.

Michelle L. Krishnan, Juliette Van Steenwinckel, Anne‐Laure Schang…·Pierre Gressèns

This paper identifies DLG4 (PSD95) expression in microglia and links genetic variation in DLG4 to white matter structure in preterm infants.

105 citationstop 1%

mousehuman

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