Bobbi Fleiss

Validated LC-MS/MS quantification of kynurenine pathway metabolites and pathway-balance ratios in brain tissue and microglial culture supernatant: application to neonatal stroke

The paper validates an LC-MS/MS method to quantify kynurenine pathway metabolites and ratios in brain tissue and microglial supernatant, showing altered ratios after neonatal stroke.

A Minimally Invasive, Scalable and Reproducible Neonatal Rat Model of Severe Focal Brain Injury

This paper introduces a new neonatal rat model of focal brain injury that is minimally invasive, scalable, and reproducible, showing consistent lesion volumes and functional outcomes.

C-section and systemic inflammation synergize to disrupt the neonatal gut microbiota and brain development in a model of prematurity

This study shows that C-sections combined with systemic inflammation worsen brain and gut issues in a preterm mouse model, increasing neurodevelopmental risks.

Epigenome priming dictates transcription response and white matter fate upon perinatal inflammation

The paper shows that neuroinflammation in OPCs causes major transcriptomic changes by exploiting a primed epigenetic landscape rather than altering chromatin accessibility, leading to white matter injury.

A unique cerebellar pattern of microglia activation in a mousemodel of encephalopathy of prematurity

This study investigates the effects of perinatal inflammation on cerebellar development in a mouse model of encephalopathy of prematurity, finding unique microglia activation and type I interferon signaling dysregulation in the cerebellum.

Perinatal IL-1-induced Inflammation Suppresses Tbr2+ Intermediate Progenitor Cell Proliferation in the Developing Hippocampus accompanied by Long-Term Behavioral Deficits

This study shows that perinatal IL-1-induced inflammation reduces Tbr2+ progenitor cell proliferation in the hippocampus, leading to long-term anxiety and spatial memory deficits in mice.

Loss of the Wnt/β-catenin pathway in microglia of the developing brain drives pro-inflammatory activation leading to white matter injury

The paper shows that reduced Wnt/β-catenin signaling in microglia of the developing brain causes pro-inflammatory activation and white matter injury, and that restoring this pathway can prevent these effects.

Integrative genomics study of microglial transcriptome reveals effect of DLG4 (PSD95) on white matter in preterm infants.

This paper identifies DLG4 (PSD95) expression in microglia and links genetic variation in DLG4 to white matter structure in preterm infants.