Tifenn Le Charpentier

PPARgamma, a key modulator of metabolic reprogramming, stemness and chemoresistance associated with retrodifferentiation in human hepatocellular carcinomas

This study identifies PPARgamma as a key regulator of metabolic reprogramming and stemness in hepatic CSCs, linking it to chemoresistance in HCC.

Epigenome priming dictates transcription response and white matter fate upon perinatal inflammation

The paper shows that neuroinflammation in OPCs causes major transcriptomic changes by exploiting a primed epigenetic landscape rather than altering chromatin accessibility, leading to white matter injury.

Perinatal IL-1-induced Inflammation Suppresses Tbr2+ Intermediate Progenitor Cell Proliferation in the Developing Hippocampus accompanied by Long-Term Behavioral Deficits

This study shows that perinatal IL-1-induced inflammation reduces Tbr2+ progenitor cell proliferation in the hippocampus, leading to long-term anxiety and spatial memory deficits in mice.

Loss of the Wnt/β-catenin pathway in microglia of the developing brain drives pro-inflammatory activation leading to white matter injury

The paper shows that reduced Wnt/β-catenin signaling in microglia of the developing brain causes pro-inflammatory activation and white matter injury, and that restoring this pathway can prevent these effects.

Integrative genomics study of microglial transcriptome reveals effect of DLG4 (PSD95) on white matter in preterm infants.

This paper identifies DLG4 (PSD95) expression in microglia and links genetic variation in DLG4 to white matter structure in preterm infants.